| # | Title | May 22 - 25 | % Chg. | Theaters | Weeks | AVG | Cumulative | ||
| 1 | Night at the Museum: Battle of the Smithsonian | $ 70,052,004 | 4,096 | 1 | $ 17,103 | $ 70,052,004 | |||
| 2 | Terminator Salvation | 51,943,726 | 3,530 | 1 | 14,715 | 65,316,217 | |||
| 3 | Star Trek | 29,380,384 | -31.7 | 4,053 | 3 | 7,249 | 191,014,403 | ||
| 4 | Angels & Demons | 27,413,992 | -40.7 | 3,527 | 2 | 7,773 | 87,524,618 | ||
| 5 | Dance Flick | 12,622,450 | 2,450 | 1 | 5,152 | 12,622,450 | |||
| 6 | X-Men Origins: Wolverine | 9,910,686 | -32.6 | 3,183 | 4 | 3,114 | 165,164,423 | ||
| 7 | Ghosts of Girlfriends Past | 4,767,809 | -28.3 | 2,255 | 4 | 2,114 | 46,906,154 | ||
| 8 | Obsessed | 2,424,470 | -47.2 | 1,603 | 5 | 1,512 | 66,332,824 | ||
| 9 | Monsters vs. Aliens | 2,060,680 | -35.2 | 1,434 | 9 | 1,437 | 193,706,544 | ||
| 10 | 17 Again | 1,292,506 | -61.6 | 1,107 | 6 | 1,168 | 60,601,427 |
Source: Box Office Guru
