| # | Title | May 15 - 17 | % Chg. | Theaters | Weeks | AVG | Cumulative | ||
| 1 | Angels & Demons | $ 46,204,168 | 3,527 | 1 | $ 13,100 | $ 46,204,168 | |||
| 2 | Star Trek | 43,034,547 | -42.8 | 3,860 | 2 | 11,149 | 147,645,384 | ||
| 3 | X-Men Origins: Wolverine | 14,702,425 | -44.3 | 3,892 | 3 | 3,778 | 150,993,169 | ||
| 4 | Ghosts of Girlfriends Past | 6,653,384 | -35.1 | 3,150 | 3 | 2,112 | 39,855,222 | ||
| 5 | Obsessed | 4,588,973 | -30.0 | 2,634 | 4 | 1,742 | 62,610,148 | ||
| 6 | 17 Again | 3,368,189 | -20.4 | 2,450 | 5 | 1,375 | 58,363,111 | ||
| 7 | Monsters vs. Aliens | 3,182,085 | -2.4 | 1,951 | 8 | 1,631 | 190,733,766 | ||
| 8 | The Soloist | 2,402,801 | -39.2 | 2,022 | 4 | 1,188 | 27,505,154 | ||
| 9 | Next Day Air | 2,244,878 | -45.4 | 1,139 | 2 | 1,971 | 7,613,221 | ||
| 10 | Earth | 1,697,956 | -36.3 | 1,584 | 4 | 1,072 | 29,088,771 |
Source: Box Office Guru
